New Paper in Acta Biomaterialia - Microstructure Governs Corrosion and Aluminum Fate in Biodegradable Mg-Al Alloys
📄 New Paper Published in Acta Biomaterialia
Our paper, “Microstructure Regulates Corrosion Behavior and Systemic Aluminum Fate in Biodegradable Mg-Al Alloys: Integrated In-Vitro and In-Vivo Insights,” has been published in Acta Biomaterialia.
Research Summary
Biodegradable magnesium alloys are designed to gradually disappear after fulfilling their mechanical function, but degradation also releases alloying elements into the surrounding biological environment.
In this study, we investigated how processing-driven microstructural changes influence corrosion behavior, aluminum release, and the subsequent biological fate of aluminum in Mg-Al alloys.
By integrating materials characterization, in-vitro corrosion testing, and in-vivo analysis, we show that microstructure plays a central role not only in determining how quickly an alloy corrodes, but also in controlling how alloying elements are released and transported after degradation.
Acknowledgments
I am grateful to Mitchell Connon, Camryn Byrum, Rohit Berlia, Veronica Ivanovskaya, Beril Ulugun, Suhas Eswarappa Prameela, Roger J. Guillory II, and Prof. Timothy P. Weihs for their contributions to this interdisciplinary work.
Publication Details
Journal: Acta Biomaterialia
Volume: 208
Pages: 565-580
Year: 2025
DOI: 10.1016/j.actbio.2025.10.046
The study highlights why the design of biodegradable metallic implants must connect processing, microstructure, corrosion, and biological response, rather than treating them as separate problems.